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- * Bacterial regulatory proteins, deoR family signature *
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-
- The many bacterial transcription regulation proteins which bind DNA through a
- 'helix-turn-helix' motif can be classified into subfamilies on the basis of
- sequence similarities. One of these subfamilies groups together the following
- proteins [1,2]:
-
- - accR, the Agrobacterium tumefaciens plasmid pTiC58 repressor of opine
- catabolism and conjugal transfer.
- - deoR, the Escherichia coli deoxyribose operon repressor.
- - fucR, the Escherichia coli L-fucose operon activator.
- - gatR, the Escherichia coli galacticol operon repressor.
- - glpR, the Escherichia coli glycerol-3-phosphate regulon repressor.
- - gutR (or srlR), the Escherichia coli glucitol operon repressor.
- - lacR, the streptococci lactose phosphotransferase system repressor.
- - yihW, an Escherichia coli hypothetical protein.
-
- The 'helix-turn-helix' DNA-binding motif of these proteins is located in the
- N-terminal part of the sequences. The pattern we use to detect these proteins
- starts fourteen residues before the HTH motif and ends one residue after it.
-
- -Consensus pattern: R-x(3)-[LIVM]-x(3)-[LIVM]-x(20)-T-[LIVMA]-R-[KRA]-D-[LIVM]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / Pattern and text revised.
-
- [ 1] von Bodman S., Hayman G.T., Farrand S.K.
- Proc. Natl. Acad. Sci. U.S.A. 89:643-647(1992).
- [ 2] Bairoch A.
- Unpublished observations (1993).
-